International Chemical Safety Cards N-NITROSODIMETHYLAMINE ICSC: 0525 Dimethylnitrosamine N-Methyl-N-nitrosomethylamine DMN C2H6N2O / (CH3)2NN=O Molecular mass: 74.1 ICSC #    0525 CAS #     62-75-9 RTECS # IQ0525000 UN #        2810 EC #         612-077-00-3 March 13, 2001 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. Powder, carbon dioxide. EXPLOSION EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Sore throat. Cough. Nausea. Diarrhoea. Vomiting. Headache. Weakness. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN Redness. Pain. Protective gloves. Remove contaminated clothes. Rinse skin with plenty of water or shower.  •EYES Pain. Redness. Face shield, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Abdominal cramps. (Further see Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Evacuate danger area! Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Chemical protection suit including self-contained breathing apparatus. Separated from strong oxidants, food and feedstuffs . Cool. Keep in the dark. Well closed. Do not transport with food and feedstuffs. Unbreakable packaging; put breakable packaging into closed unbreakable container. Note: E T+ symbol N symbol R: 45-25-26-48/25-51/53 S: 53-45-61 UN Hazard Class: 6.1 UN Packing Group: I SEE IMPORTANT INFORMATION ON BACK ICSC: 0525 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards N-NITROSODIMETHYLAMINE ICSC: 0525 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: YELLOW OILY LIQUID PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing nitrogen oxides . Reacts with strong oxidants and strong bases . OCCUPATIONAL EXPOSURE LIMITS: TLV: A3, skin (ACGIH 2000). MAK: Class 2 (2000) OSHA PEL: 1910.1016 See Appendix B NIOSH REL: Ca See Appendix A NIOSH IDLH: Potential occupational carcinogen No data ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and by ingestion. INHALATION RISK: No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes, the skin and the respiratory tract. The substance may cause effects on the liver , resulting in jaundice. The effects may be delayed. See Notes. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the liver , resulting in liver function impairment and cirrhosis. This substance is probably carcinogenic to humans. PHYSICAL PROPERTIES Boiling point: 151°C Relative density (water = 1): 1.0 Solubility in water: very good Vapour pressure, Pa at 20°C: 360 Relative vapour density (air = 1): 2.56 Flash point: 61°C Octanol/water partition coefficient as log Pow: -0.57 ENVIRONMENTAL DATA N O T E S The symptoms of jaundice do not become manifest until some hours have passed. Environmental effects from the substance have not been investigated adequately . Transport Emergency Card: TEC (R)-61G61b ADDITIONAL INFORMATION ICSC: 0525 N-NITROSODIMETHYLAMINE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.