International Chemical Safety Cards 4,4'-METHYLENE BIS(2-CHLOROANILINE) ICSC: 0508 Benzenamine, 4,4'-methylenebis(2-chloro-) 2,2'-Dichloro-4,4'-methylenedianiline 4,4'-Diamino-3,3'-dichlorodiphenylmethane MOCA; MBOCA C13H12Cl2N2 Molecular mass: 267.2 ICSC #    0508 CAS #     101-14-4 RTECS # CY1050000 EC #         612-078-00-9 November 24, 1998 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. In case of fire in the surroundings: all extinguishing agents allowed. EXPLOSION EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Blue lips or finger nails. Blue skin. Confusion. Convulsions. Dizziness. Headache. Nausea. Unconsciousness. Ventilation (not if powder), local exhaust, or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN MAY BE ABSORBED! Burning sensation. (Further see Inhalation). Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Safety goggles, or face shield, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Abdominal pain. (See Inhalation). Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING If in molten state, let solidify. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment. (Extra personal protection: complete protective clothing including self-contained breathing apparatus). See Chemical Dangers. Well closed. Note: E T symbol N symbol R: 45-22-50/53 S: 53-45-60-61 SEE IMPORTANT INFORMATION ON BACK ICSC: 0508 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards 4,4'-METHYLENE BIS(2-CHLOROANILINE) ICSC: 0508 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS CRYSTALS OR LIGHT BROWN PELLETS PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating above 200°C or on burning producing toxic and corrosive fumes including hydrogen chloride and nitrogen oxides. The substance is a weak base. Reacts with some metals such as aluminium, magnesium and potassium. OCCUPATIONAL EXPOSURE LIMITS: TLV (as TWA): 0.01 ppm; 0.11 mg/m3 A2 (skin) (ACGIH 1998). OSHA PEL: none NIOSH REL: Ca TWA 0.003 mg/m3 skin See Appendix A NIOSH IDLH: Potential occupational carcinogen No data ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. INHALATION RISK: A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the blood , resulting in formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: This substance is probably carcinogenic to humans. May cause genetic damage in humans. PHYSICAL PROPERTIES Melting point: 110°C Density: 1.44 g/cm3 Solubility in water: none Octanol/water partition coefficient as log Pow: 3.94 ENVIRONMENTAL DATA In the food chain important to humans, bioaccumulation takes place, specifically in aquatic organisms and plants. N O T E S Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Bisamine S, Bisamine A, Cuamine M, Cuamine MT, Curalin M, Curalon M, Curene 442, Diamet Kh are trade names. ADDITIONAL INFORMATION ICSC: 0508 4,4'-METHYLENE BIS(2-CHLOROANILINE) (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.