International Chemical Safety Cards CAFFEINE ICSC: 0405 1,3,7-Trimethylxanthine 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione Methyltheobromine Methyltheophylline C8H10N4O2 Molecular mass: 194.19 ICSC #    0405 CAS #     58-08-2 RTECS # EV6475000 UN #        1544 EC #         613-086-00-5 March 27, 1998 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Water spray, powder. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST!  •INHALATION (See Ingestion). Local exhaust or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN Protective gloves. Remove contaminated clothes. Rinse skin with plenty of water or shower.  •EYES Safety spectacles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Headache. Dizziness. Abdominal cramps. Nausea. Vomiting. Convulsions. Tremors. Do not eat, drink, or smoke during work. Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Personal protection: P2 filter respirator for harmful particles. Separated from food and feedstuffs . Well closed. Do not transport with food and feedstuffs. Xn symbol R: 22 S: 2 UN Hazard Class: 6.1 SEE IMPORTANT INFORMATION ON BACK ICSC: 0405 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards CAFFEINE ICSC: 0405 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: ODOURLESS WHITE CRYSTALS OR CRYSTALLINE POWDER. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on burning producing toxic fumes including nitrogen oxides . OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on dust forming. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the central nervous system and cardiovascular system , resulting in insomnia, excitement, tachycardia, polyuria. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Animal tests show that this substance possibly causes toxic effects upon human reproduction. PHYSICAL PROPERTIES Sublimation point: 178°C Melting point: 238°C Density: 1.23 g/cm3 Solubility in water, g/100 ml: 2.17 Octanol/water partition coefficient as log Pow: -0.07 ENVIRONMENTAL DATA N O T E S Transport Emergency Card: TEC (R)-61G67 ADDITIONAL INFORMATION ICSC: 0405 CAFFEINE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.