International Chemical Safety Cards METHYLENE BISPHENYL ISOCYANATE ICSC: 0298 Diphenylmethane-4.4'-diisocyanate bis(1,4-Isocyanatophenyl)methane MDI 4,4'-Methylenediphenyldiisocyanate C15H10N2O2 / OCNC6H4CH2C6H4NCO Molecular mass: 250.3 ICSC #    0298 CAS #     101-68-8 RTECS # NQ9350000 EC #         615-005-00-9 March 25, 1999 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, carbon dioxide. EXPLOSION EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Headache. Nausea. Shortness of breath. Sore throat. Local exhaust or breathing protection. Fresh air, rest. Artificial respiration if indicated. Refer for medical attention.  •SKIN Redness. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.  •EYES Pain. Safety goggles or face shield. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Do not eat, drink, or smoke during work. Rinse mouth. Do NOT induce vomiting. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Evacuate danger area! Consult an expert! Sweep spilled substance into sealable containers. Carefully collect remainder, then remove to safe place. Chemical protection suit including self-contained breathing apparatus. Separated from incompatible materials (see Chemical Dangers), food and feedstuffs . Cool. Dry. Keep in the dark. Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs. Note: C Xn symbol R: 20-36/37/38-42/43 S: 1/2-23-36/37-45 SEE IMPORTANT INFORMATION ON BACK ICSC: 0298 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards METHYLENE BISPHENYL ISOCYANATE ICSC: 0298 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: WHITE TO PALE YELLOW CRYSTALS OR FLAKES. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance may polymerize under the influence of temperatures above 204°C. On combustion, forms toxic and corrosive fumes including nitrogen oxides and hydrogen cyanide (see ICSC 0492). Reacts readily with water to form insoluble polyureas. Reacts violently with acids, alcohols, amines, bases and oxidants causing fire and explosion hazard. OCCUPATIONAL EXPOSURE LIMITS: TLV: 0.005 ppm; as TWA (ACGIH 1998). OSHA PEL: C 0.2 mg/m3 (0.02 ppm) NIOSH REL: TWA 0.05 mg/m3 (0.005 ppm) C 0.2 mg/m3 (0.020 ppm) 10-minute NIOSH IDLH: 75 mg/m3 ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. EFFECTS OF SHORT-TERM EXPOSURE: Tear drawing. The substance irritates the eyes, the skin and the respiratory tract. The substance may cause effects on the lungs , resulting in impaired functions. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma (see Notes). PHYSICAL PROPERTIES Boiling point at 100 kPa: 314°C Melting point: 37°C Relative density (water = 1): 1.2 Solubility in water: reaction Vapour pressure, Pa at 20°C: negligible Relative vapour density (air = 1): 8.6 Flash point: 196°C c.c. Auto-ignition temperature: 240°C ENVIRONMENTAL DATA N O T E S The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. MDI may sensitize workers so that they react to other isocyanates (asthma). Do NOT take working clothes home. Caradate 30, Desmodur 44, Hylene M 150, Isonate, Nacconate 300, NCI-C50668, Rubinate 44 are trade names. ADDITIONAL INFORMATION ICSC: 0298 METHYLENE BISPHENYL ISOCYANATE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.