International Chemical Safety Cards HEXAMETHYLPHOSPHORIC TRIAMIDE ICSC: 0162 Hexamethylphosphoramide Hexamethylphosphamide HMPA C6H18N3OP / {(CH3)2N}3P(O) Molecular mass: 179.2 ICSC #    0162 CAS #     680-31-9 RTECS # TD0875000 EC #         015-106-00-2 October 27, 1994 Peer reviewe TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, alcohol-resistant foam, water spray, carbon dioxide. EXPLOSION EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Ventilation, local exhaust, or breathing protection. Refer for medical attention.  •SKIN MAY BE ABSORBED! Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Safety spectacles or face shield . First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: self-contained breathing apparatus. Ventilation along the floor. T symbol R: 45-46 S: 53-45 SEE IMPORTANT INFORMATION ON BACK ICSC: 0162 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards HEXAMETHYLPHOSPHORIC TRIAMIDE ICSC: 0162 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS MOBILE LIQUID. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating or on burning producing toxic fumes including phosphorus oxides nitrogen oxides . OCCUPATIONAL EXPOSURE LIMITS: TLV: A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2004). MAK: skin absorption (H); Carcinogen category: 2; (DFG 2004). OSHA PEL: none NIOSH REL: Ca See Appendix A NIOSH IDLH: No data ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and through the skin. INHALATION RISK: No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the lungs , kidneys and central nervous system , resulting in impaired functions and depression. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the respiratory tract,kidneysandbone marrow. This substance is possibly carcinogenic to humans. May cause genetic damage in humans. PHYSICAL PROPERTIES Boiling point: 232°C Melting point: 5-7°C Relative density (water = 1): 1.03 Solubility in water: very good Vapour pressure, Pa at 20°C: 4 Relative vapour density (air = 1): 6.18 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 105°C ENVIRONMENTAL DATA N O T E S Depending on the degree of exposure, periodic medical examination is suggested. Hexametapol is a trade name. Card has been partly updated in April 2005. See section Occupational Exposure Limits. ADDITIONAL INFORMATION ICSC: 0162 HEXAMETHYLPHOSPHORIC TRIAMIDE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.