International Chemical Safety Cards 2-CHLORO-1-NITROBENZENE ICSC: 0028 o-Chloronitrobenzene o-Nitrochlorobenzene 1-Chloro-2-nitrobenzene C6H4ClNO2 Molecular mass: 157.6 ICSC #    0028 CAS #     88-73-3 RTECS # CZ0875000 UN #        1578 October 10, 2002 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. NO contact with flammable substances. Powder, water spray, foam, carbon dioxide. EXPLOSION Finely dispersed particles form explosive mixtures in air. Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting. EXPOSURE PREVENT DISPERSION OF DUST! STRICT HYGIENE!  •INHALATION Blue lips or finger nails. Blue skin. Dizziness. Headache. Nausea. Shortness of breath. Confusion. Convulsions. Unconsciousness. Local exhaust or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN MAY BE ABSORBED! (Further see Inhalation). Protective gloves. Protective clothing. First rinse with plenty of water, then remove contaminated clothes and rinse again. Refer for medical attention.  •EYES Redness. Pain. Safety goggles or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Do not eat, drink, or smoke during work. Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT absorb in saw-dust or other combustible absorbents. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus. Separated from combustible and reducing substances, food and feedstuffs . Do not transport with food and feedstuffs. R: S: UN Hazard Class: 6.1 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 0028 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards 2-CHLORO-1-NITROBENZENE ICSC: 0028 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: YELLOW TO GREEN CRYSTALS , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: Dust explosion possible if in powder or granular form, mixed with air. CHEMICAL DANGERS: The substance decomposes on burning producing toxic and corrosive fumes ( nitrogen oxides , chlorine - see ICSC0126, hydrogen chloride - see ICSC0163, phosgene - see ICSC0007). The substance is a strong oxidant and reacts with combustible and reducing materials. OCCUPATIONAL EXPOSURE LIMITS: TLV not established.(See Notes). BEI issued MAK: skin absorption (H); Carcinogen category: 3B; (DFG 2004). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. INHALATION RISK: A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is mildly irritating to the eyes . The substance may cause effects on the blood , resulting in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the blood and liver , resulting in the formation of methaemoglobin, anaemia and liver impairment . PHYSICAL PROPERTIES Boiling point: 246°C Melting point: 33°C Density: 1.4 g/cm3 Solubility in water: none Vapour pressure, kPa at 20°C: 0.6 Relative vapour density (air = 1): 5.4 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.03 Flash point: 124°C c.c. Auto-ignition temperature: 487°C Explosive limits, vol% in air: 1.15-13.1 Octanol/water partition coefficient as log Pow: 2.24 ENVIRONMENTAL DATA The substance is harmful to aquatic organisms. N O T E S TLV (as para-nitrochlorobenzene): 0.1 ppm (skin) A3 (confirmed animal carcinogen with unknown relevance to humans) (ACGIH 2004). Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Rinse contaminated clothes (fire hazard) with plenty of water. Card has been partly updated in April 2005. See section Occupational Exposure Limits. Transport Emergency Card: TEC (R)-61S1578-S NFPA Code: H3; F1; R1; ADDITIONAL INFORMATION ICSC: 0028 2-CHLORO-1-NITROBENZENE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.