Documentation for Immediately Dangerous to Life or Health Concentrations (IDLHs)

Vanadium dust

IDLH Documentation CAS number: 1314621

NIOSH REL: 0.05 mg V/m³ 15minute CEILING

Current OSHA PEL: 0.5 mg V₂O₅/m³ (respirable dust) CEILING

1989 OSHA PEL: 0.05 mg V₂O₅/m³ (respirable dust) TWA

19931994 ACGIH TLV: 0.05 mg V₂O₅/m³ (respirable dust) TWA

Description of substance: Yelloworange powder or darkgray, odorless flakes dispersed in air.

LEL: . . Noncombustible Solid

Original (SCP) IDLH: 70 mg/m³ (as V₂O₅)

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that vanadium pentoxide dust at 70 mg/m³ is fatal to animals within a few hours [Hudson 1964]. AIHA [1957] reported that rabbits succumb from edema of the lungs at 200 mg/m³ after one 7hour exposure [Sjoberg 1950].

Shortterm exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species	Reference	LC₅₀	LC_Lo	Time	Adjusted 0.5-hr LC (CF)	Derived value
Cat	Faulkner 1964	-----	500 mg/m³	23 min	256 mg V/m³ (0.915)	26 mg V/m³
Rat	Izrael'son 1963	-----	70 mg/m³	2 hr	63 mg V/m³ (1.6)	6.3 mg V/m³

Lethal dose data:

Species	Reference	Route	LD₅₀ (mg/kg)	LD_Lo (mg/kg)	Adjusted LD	Derived value
Rat	Arch Toxikol 1956	oral	10	-----	39 mg V/m³	3.9 mg V/m³
Mouse	Izmerov et al. 1982	oral	23	-----	90 mg V/m³	9.0 mg V/m³

Human data: Respiratory irritation following exposures to V₂O₅ ranging from 1 to 48 mg V/m³ has been described in workers [Sjoberg 1955]. Vanadium intoxication (i.e., rhinorrhea, sneezing, lacrimation, and sore throat) has been reported in workers exposed to concentrations of V₂O₅ during the workshift ranging from 10 to 33 mg/m³ [Williams 1952]. Concentrations of V₂O₅ exceeding 56 mg V/m³ have resulted in local respiratory effects [Vintinner et al. 1955]. Other workers exposed intermittently to 56 mg V/m³ showed no evidence of intoxication [McTurk et al. 1956].

Revised IDLH: 35 mg V/m³

Basis for revised IDLH: Based on acute inhalation toxicity data in workers [McTurk et al. 1956; Sjoberg 1955; Vintinner et al. 1955; Williams 1952], the revised IDLH for vanadium dust is 35 mg V/m³.

REFERENCES:

1. ACGIH [1971]. Vanadium (as V). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 275276.

2. AIHA [1957]. Vanadium pentoxide. In: Hygienic guide series. Am Ind Hyg Assoc Q 18:172173.

3. Arch Toxikol [1956]; 16:182189 (in German).

4. Faulkner TG [1964]. Vanadium toxicology and biological significance. New York, NY: Elsevier Science Publishing Co., p. 72.

5. Hudson TGF [1964]. Vanadium: toxicology and biological significance. New York, NY: Elsevier Publishing Company, p. 75.

6. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 119.

7. Izrael'son ZI, ed. [1963]. Toxicology of the rare metals. Jerusalem, Israel: Israel Program for Scientific Translations.

8. McTurk LC, Hirs CHW, Eckard RE [1956]. Health hazards of vanadiumcontaining residual oil ash. Ind Med Surg 25:2936.

9. Sjoberg SG [1950]. Vanadium pentoxide dust: a clinical and experimental investigation on its effect after inhalation. Acta Med Scand Suppl 238:8199.

10. Sjoberg SG [1955]. Vanadium bronchitis from cleaning oilfired boilers. AMA Arch Ind Health 11:505512.

11. Vintinner FJ, Vallenas R, Carlin CE, Weiss R, Macher C, Ochoa R [1955]. Study of the health of workers employed in mining and processing of vanadium ore. AMA Arch Ind Health 12:635642.

12. Williams N [1952]. Vanadium poisoning from cleaning oilfired boilers. Brit J Ind Med 9:5055.

Go back to the Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)