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NIOSH REL: None established; NIOSH considers otoluidine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990] that may be absorbed through the skin.
Current OSHA PEL: 5 ppm (22 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
19931994 ACGIH TLV: 2 ppm (8.8 mg/m3) TWA [skin], A2
Description of substance: Colorless to paleyellow liquid with an aromatic, anilinelike odor.
LEL: . . Unknown
Original (SCP) IDLH: 100 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Sax [1975] that 100 ppm is the maximum concentration endurable for 1 hour without serious consequences. No other data are available on which to base the IDLH.
Shortterm exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal dose data:
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| Rat
Mouse Rabbit Rat Rat | IARC 1982
IARC 1982 IARC 1982 Jacobsen 1972 Jacobsen 1972 |
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Other animal data: Rats have survived an 8hour exposure to saturated vapors of otoluidine [Smyth et al. 1962].
Human data: It has been reported that a 60minute
exposure to 40 ppm produces severe toxic effects [Goldblatt
1955]. It has been reported that 100 ppm is the maximum concentration
endurable for 1 hour without serious consequences [Sax 1975].
| Revised IDLH: 50 ppm
Basis for revised IDLH: The revised IDLH for otoluidine is 50 ppm based on acute inhalation toxicity data in humans [Goldblatt 1955; Sax 1975]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for otoluidine at any detectable concentration.] |
REFERENCES:
1. Goldblatt MW [1955]. Research in industrial health in the chemical industry. Brit J Ind Med 12:120.
2. IARC [1982]. orthoToluidine and its hydrochloride. In: IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol. 27. Some aromatic amines, anthraquinones and nitroso compounds, and inorganic fluorides used in drinkingwater and dental preparations, pp. 155175.
3. Jacobsen KH [1972]. Short communication: acute oral toxicity of mono and dialkyl ringsubstituted derivatives of aniline. Toxicol Appl Pharmacol 22:153154.
4. Sax NI [1975]. oToluidine. In: Dangerous properties of industrial materials. 4th ed. New York, NY: Van Nostrand Reinhold Company, pp. 11731176.
5. Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962].
Rangefinding toxicity data: list VI. Am Ind Hyg Assoc
J 23:95107.
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