TEDP

IDLH Documentation
CAS number: 89­24­5

NIOSH REL: 0.2 mg/m3 TWA [skin]

Current OSHA PEL: 0.2 mg/m3 TWA [skin]

1989 OSHA PEL: Same as current PEL

1993­1994 ACGIH TLV: 0.2 mg/m3 TWA [skin]

Description of substance: Pale­yellow liquid with a garlic­like odor.

LEL :. . Unknown

Original (SCP) IDLH: 35 mg/m3

Basis for original (SCP) IDLH: The chosen IDLH is based on the rat oral LD50 of 5 mg/kg [Lehman 1951 cited by ACGIH 1971]. No other useful data are available on which to base the IDLH.

Short­term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species
Reference
LC50
LCLo
Time
Adjusted 0.5-hr

LC (CF)
Derived value
RatKimmerle & Klimmer 1974
38 mg/m3
-----
4 hr
76 mg/m3 (2.0)
7.6 mg/m3
MouseKimmerle & Klimmer 1974
40 mg/m3
-----
4 hr
80 mg/m3 (2.0)
8.0 mg/m3

Lethal dose data:

Species
Reference
Route
LD50

(mg/kg)
LDLo

(mg/kg)
Adjusted LD
Derived value
MouseKimmerle & Klimmer 1974
oral
22
-----
154 mg/m3
15 mg/m3
RabbitKimmerle &Klimmer 1974
oral
25
-----
175 mg/m3
18 mg/m3
DogKimmerle & Klimmer 1974
oral
5
-----
35 mg/m3
3.5 mg/m3
RatLehman 1951
oral
5
-----
35 mg/m3
3.5 mg/m3

Other animal data: It has been stated that TEDP is an organophosphate pesticide whose toxicity is similar to that of parathion [ACGIH 1991].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 10 mg/m3

Basis for revised IDLH: The revised IDLH for TEDP is 10 mg/m3 based on acute inhalation toxicity data in animals [Kimmerle and Klimmer 1974] and on an analogy with parathion [ACGIH 1991] which has a revised IDLH of 10 mg/m3.

REFERENCES:

1. ACGIH [1971]. TEDP (tetraethyl dithionopyrophosphate). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 244­245.

2. ACGIH [1991]. Sulfotep. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1452­1454.

3. Kimmerle G, Klimmer OR [1974]. Acute and subchronic toxicity of sulfotep. Arch Toxicol 33:1­16.

4. Lehman AJ [1951]. Chemicals in foods: A report to the Association of Food and Drug Officials on current developments. Part II. Pesticides. Section II. Dermal Toxicity.  Q Bulletin Assoc Food Drug Off U.S. 16(1):3­9. Go back to the Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)