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NIOSH REL: 0.05 ppm (0.2 mg/m3) TWA
Current OSHA PEL: 0.05 ppm (0.2 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.05 ppm (0.16 mg/m3) TWA
Description of Substance: Colorless gas with an odor resembling decayed horse radish.
LEL:. . Unknown
Original (SCP) IDLH: 2 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the report by Dudley and Miller [1941] that "12.5% of the guinea pigs which had been exposed for 2 hours at 1.8 ppm (0.006 mg/l) died within 30 days of the exposure. A 4hour exposure to 1.8 ppm was lethal to 18.8% of the guinea pigs exposed, and a 4hour exposure to 2.1 ppm was lethal to 25% of the animals exposed."
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
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| G. pig | Dudley and Miller 1941 | |||||
| G. pig | Dudley and Miller 1941 | |||||
| G. pig | Dudley and Miller 1941 | |||||
| G. pig | Dudley and Miller 1941 | |||||
| Rat | Wilber 1980 |
Human data: Although very toxic, no fatalities have been
reported, possibly because hydrogen selenide is easily oxidized
to red selenium on the surface of mucous membranes of the nose
and throat [Friberg et al. 1979]. Concentrations of 1.5 ppm
have been found to be intolerable due to eye and nasal irritation
[Dudley and Miller 1941].
| Revised IDLH: 1 ppm
Basis for revised IDLH: The revised IDLH for hydrogen selenide is 1 ppm based on acute inhalation data in humans [Dudley and Miller 1941; Friberg et al. 1979]. |
REFERENCES:
1. Dudley HC, Miller JW [1941]. Toxicology of selenium. VI. Effects of subacute exposure to hydrogen selenide. J Ind Hyg Toxicol 23(10):470477.
2. Friberg L, Nordberg GR, Vouk VB [1979]. Handbook on the toxicology of metals. New York, NY: Elsevier North Holland, p. 568.
3. Wilber CG [1980]. Toxicology of selenium: a review. Clin Toxicol 17(2):171230.
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