Ammonium sulfamate

CAS number . . . . . . . . . . . 7773-06-0
NIOSH REL. . . . . . . . . . . . 10 mg/m3 (total dust) TWA, 5 mg/m3
                                 (respirable dust) TWA
Current OSHA PEL . . . . . . . . 15 mg/m3 (total dust) TWA, 5 mg/m3
                                 (respirable dust) TWA
1989 OSHA PEL. . . . . . . . . . 10 mg/m3 (total dust) TWA, 5 mg/m3
                                 (respirable dust) TWA
1993-1994 ACGIH TLV. . . . . . . 10 mg/m3 TWA
Description of substance . . . . Colorless to white crystalline, odorless
                                 solid.
LEL. . . . . . . . . . . . . . . Noncombustible Solid
Original (SCP) IDLH. . . . . . . 5,000 mg/m3
Basis for original (SCP) IDLH. . The chosen IDLH is based on the rat
                                 intraperitoneal LDLO of 800 mg/kg cited by
                                 NIOSH [1976] from Ambrose [1943].  This
                                 compound has a low toxicity.
Short-term exposure guidelines . None developed

ACUTE TOXICITY DATA

Lethal dose data:

                                                                              
                                    LD50    LDLo                     Derived
Species     Reference       Route (mg/kg) (mg/kg)    Adjusted LD      Value
______________________________________________________________________________
Rat      Ball 1956          oral   2,000   -----    14,000 mg/m3   1,400 mg/m3
Mouse    Gig Tr Prof Zabol  oral   3,100   -----    21,700 mg/m3   2,170 mg/m3
         1963
Rat      Lehman 1951        oral   3,900   -----    27,300 mg/m3   2,730 mg/m3
Mouse    Lehman 1951        oral   5,760   -----    40,320 mg/m3   4,032 mg/m3

                                  
Human data . . . . . . . . . . . None relevant for use in determining the
                                 revised IDLH.

Revised IDLH: 1,500 mg/m3
Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for ammonium sulfamate. Therefore, the revised IDLH for ammonium sulfamate is 1,500 mg/m3 based on the acute oral toxicity data in animals [Ball 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

REFERENCES:

1. Ambrose AM [1943]. Studies of the physiological effects of sulfamic acid and ammonium sulfamate. J Ind Hyg Toxicol 25:26.
2. Ball WL [1956]. Threshold limits for pesticides. AMA Arch Ind Health 14:178-185.
3. Gig Tr Prof Zabol [1963]; 7(5):56-57 (in Russian).
4. Lehman AJ [1951]. Chemicals in foods: a report to the Association of Food and Drug Officials on current developments. Part II. Pesticides. Q Bulletin Assoc Food Drug Off U.S. 15(4):122-125.
5. NIOSH [1976]. WO61250. Sulfamic acid, monoammonium salt. In: Registry of Toxic Effects of Chemical Substances (RTECS) 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 1111.