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NIOSH REL: 2 ppm (5 mg/m3) TWA, 4 ppm (10 mg/m3) STEL
Current OSHA PEL: 2 ppm (5 mg/m3) TWA
1989 OSHA PEL: 2 ppm (5 mg/m3) TWA, 4 ppm (10 mg/m3) STEL
1993-1994 ACGIH TLV: 2 ppm (5.2 mg/m3) TWA, 4 ppm (10 mg/m3) STEL
Description of substance: Colorless, yellow, or red, fuming liquid with an acrid, suffocating odor.
LEL: . . . Noncombustible Liquid
Original (SCP) IDLH: 100 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by MCA [1961] that pulmonary edema may result from an exposure of 100 to 150 ppm for only 0.5 to 1 hour. It is not clear if MCA [1961] was referring to nitric acid specifically, or to nitrogen oxides. The chosen IDLH seems reasonable, however, because an IDLH of 100 ppm was also selected for hydrogen chloride.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
| Rat | Gray et al. 1954 |
Other animal data: Rats receiving a single exposure to
63 mg/m3 nitric acid (24 ppm) exhibited no
apparent adverse effects [Diggle and Gage 1954].
Human data: A maximum allowable workplace concentration
of 10 ppm has been proposed [Fairhall 1957]. It has been
reported that 430 mg/kg is the lethal oral dose [Gekkan Yakuji
1980]. [Note: An oral dose of 430 mg/kg is equivalent to
a worker being exposed to about 2,300 ppm for 30 minutes,
assuming a breathing rate of 50 liters per minute and 100%
absorption.]
| Revised IDLH: 25 ppm
Basis for revised IDLH: The revised IDLH for nitric acid is 25 ppm based on acute toxicity data in humans [Gekkan 1980] and animals [Diggle and Gage 1954]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers. |
REFERENCES:
1. Diggle WM, Gage JC [1954]. The toxicity of nitrogen pentoxide. Br J Ind Med 11:140144.
2. Fairhall LT [1957]. Industrial toxicology. 2nd ed. Baltimore, MD: Williams & Wilkins Company, pp. 8384.
3. Gekkan Yakuji (Phamaceuticals Monthly) [1980]; 22(4):651656 (in Japanese).
4. Gray EL, Patton FM, Foldberg SB, Kaplan E [1954]. Toxicity of oxides of nitrogen. II. Acute inhalation toxicity of nitrogen dioxide, red fuming nitric acid, and white fuming nitric acid. AMA Arch Ind Hyg Occup Med 10:418422.
5. MCA [1961]. Chemical safety data sheet SD5: properties
and essential information for safe handling and use of nitric
acid. Washington, DC: Manufacturing Chemists Association, pp. 117.
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