sec-Amyl acetate

CAS number . . . . . . . . . . . 626-38-0
NIOSH REL. . . . . . . . . . . . 125 ppm (650 mg/m3) TWA
Current OSHA PEL . . . . . . . . 125 ppm (650 mg/m3) TWA
1989 OSHA PEL. . . . . . . . . . Same as current PEL
1993-1994 ACGIH TLV. . . . . . . 125 ppm (665 mg/m3) TWA
Description of substance . . . . Colorless liquid with a mild odor.
LEL. . . . . . . . . . . . . . . 1% (10% LEL, 1,000 ppm)
Original (SCP) IDLH. . . . . . . 9,000 ppm
Basis for original (SCP) IDLH. . The chosen IDLH is based on the statement by
                                 ACGIH [1971] that 9,200 ppm was lethal to
                                 guinea pigs in 7 hours [Patty et al. 1936]. 
                                 This is the only data on acute inhalation
                                 toxicity available on which to base the IDLH.
Short-term exposure guidelines . None developed

ACUTE TOXICITY DATA

Lethal concentration data:

                                                       Adjusted               
                              LC50   LCLo               0.5-hr         Derived
Species     Reference        (ppm)  (ppm)   Time        LC (CF)         Value
______________________________________________________________________________
G. pig   Patty et al. 1936   -----   9,200  7 hr  22,080 ppm (2.4)   2,208 ppm
G. pig   von Oettingen 1960  -----  10,000  5 hr  21,500 ppm (2.15)  2,150 ppm

                                  
Human data . . . . . . . . . . . It has been stated that exposure to 1,000 ppm
                                 for an hour may be expected to produce
                                 serious toxic effects [von Oettingen 1960].

Revised IDLH: 1,000 ppm
Basis for revised IDLH: The revised IDLH for sec-amyl acetate is 1,000 ppm based on acute inhalation toxicity data in humans [von Oettingen 1960] and the similarity of the toxic effects of sec-amyl acetate to those of n-amyl acetate (which also has a revised IDLH of 1,000 ppm).

REFERENCES:

1. ACGIH [1971]. sec-Amyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 13.
2. Patty FA, Yant WP, Schrenk HH [1936]. Acute response of guinea pigs to vapors of some new commercial organic compounds. XI. Secondary amyl acetate. Public Health Rep 51(25):811-819.
3. von Oettingen WF [1960]. The aliphatic acids and their esters: toxicity and potential dangers. AMA Arch Ind Health 21:40/28-77/65.