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NIOSH REL: 0.04 ppm (0.08 mg/m3) 2hour CEILING; NIOSH considers methyl hydrazine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 0.2 ppm (0.35 mg/m3) CEILING [skin]
1989 OSHA PEL: Same as current PEL
19931994 ACGIH TLV: 0.2 ppm (0.38 mg/m3) CEILING [skin], A2
Description of substance: Fuming, colorless liquid with an ammonialike odor.
LEL: . . . 2.5% (10% LEL, 2,500 ppm)
Original (SCP) IDLH: 50 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the report by Jacobson et al. [1955] of a mouse LC50 of 56 ppm.
Shortterm exposure guidelines: National Research
Council [NRC 1985] Shortterm Public Emergency Guidance Levels
(SPEGLs):
1hour SPEGL: 0.24 ppm
2hour SPEGL: 0.12 ppm
4hour SPEGL: 0.06 ppm
8hour SPEGL: 0.03 ppm
16hour SPEGL: 0.015 ppm
24hour SPEGL: 0.01 ppm
ACUTE TOXICITY DATA:
Lethal concentration data:
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Rat Monkey Dog Monkey Mouse Rat Mouse Hamster | Fairchild 1967 Haun et al. 1969 Haun et al. 1969 Haun et al. 1970 Haun et al. 1970 Haun et al. 1970 Haun et al. 1970 Jacobson et al. 1955 Jacobson et al. 1955 |
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Human data: None relevant for use in determining the revised
IDLH.
| Revised IDLH: 20 ppm
Basis for revised IDLH: The revised IDLH for methyl hydrazine is 20 ppm based on acute inhalation toxicity data in animals [Haun et al. 1969, 1970]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for methyl hydrazine at concentrations above 0.04 ppm.] |
REFERENCES:
1. Fairchild EJ II [1967]. Toxic Hazards Research Unit annual technical report: 1967. Wright-Patterson Air Force Base, OH: Aerospace Medical Research Laboratory, Report No. AMRLTR67137, pp. 158.
2. Haun CC, MacEwen JD, Vermont EH, Egan GF [1969]. The acute inhalation toxicity of monomethyl hydrazine vapor. Wright-Patterson Air Force Base, OH: Aerospace Medical Research Laboratory Report No. AMRLTR68169.
3. Haun CC, MacEwen JD, Vernot EH, Egan GF [1970]. Acute inhalation toxicity of monomethylhydrazine vapor. Am Ind Hyg Assoc J 31:667677.
4. Jacobson KH, Clem JH, Wheelwright HJ, Rinehart WE, Mayes N [1955]. The acute toxicity of the vapors of some methylated hydrazine derivatives. AMA Arch Ind Health 12:609616.
5. NRC [1985]. Emergency and continuous exposure guidance levels
for selected airborne contaminants. Vol. 5. Washington, DC:
National Academy Press, Committee on Toxicology, Board on Toxicology
and Environmental Health Hazards, Commission on Life Sciences,
National Research Council, pp. 2335.
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