Isopropyl glycidyl ether

IDLH Documentation
CAS number: 4016­14­2

NIOSH REL: 50 ppm (240 mg/m3) 15­minute CEILING

Current OSHA PEL: 50 ppm (240 mg/m3) TWA

1989 OSHA PEL: 50 ppm (240 mg/m3) TWA, 75 ppm (360 mg/m3) STEL

1993­1994 ACGIH TLV: 50 ppm (238 mg/m3) TWA, 75 ppm (356 mg/m3) STEL

Description of substance: Colorless liquid.

LEL: . . Unknown

Original (SCP) IDLH: 1,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4­hour LC50 of 1,500 ppm and the rat 8­hour LC50 of 1,100 ppm [Hine et al. 1956 cited by Patty 1963].

Short­term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species
Reference
LC50

(ppm)
LCLo

(ppm)
Time
Adjusted 0.5-hr

LC (CF)
Derived value
Mouse

Rat

Hine et al. 1956

Hine et al. 1956

1,500

1,100
-----

-----
4 hr

8 hr
3,000 ppm (2.0)

2,750 ppm (2.5)
300 ppm

275 ppm

Human data: Workers exposed to 400 ppm have suffered irritation of the eyes and respiratory tract [Hine et al. 1956].

Revised IDLH: 400 ppm

Basis for revised IDLH: The revised IDLH for isopropyl glycidyl ether is 400 ppm based on acute inhalation toxicity data in workers [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 400 ppm.

REFERENCES:

1. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250­264.

2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1638.


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