Aldrin

CAS number . . . . . . . . . . . 309-00-2
NIOSH REL. . . . . . . . . . . . 0.25 mg/m3 TWA [skin]; NIOSH considers aldrin
                                 to be a potential occupational carcinogen as
                                 defined by the OSHA carcinogen policy [29 CFR
                                 1990].
Current OSHA PEL . . . . . . . . 0.25 mg/m3 TWA [skin]
1989 OSHA PEL. . . . . . . . . . Same as current PEL
1993-1994 ACGIH TLV. . . . . . . 0.25 mg/m3 TWA [skin]
Description of substance . . . . Colorless to dark-brown crystalline solid
                                 with a mild chemical odor.
LEL. . . . . . . . . . . . . . . Noncombustible Solid
Original (SCP) IDLH. . . . . . . 100 mg/m3
Basis for original (SCP) IDLH. . No useful data on acute inhalation toxicity
                                 are available on which to base the IDLH for
                                 aldrin.  The chosen IDLH, therefore, has been
                                 estimated from the statement by Baskin [1975]
                                 that severe symptoms follow swallowing or 
                                 skin contamination with 15 to 50 mg/kg
                                 (average adult).  According to Deichmann
                                 [1973], aldrin vapor gave no effect in man at
                                 18 mg/m3 during exposure for 1 day.
Short-term exposure guidelines . None developed

ACUTE TOXICITY DATA

Lethal concentration data:

                                                       Adjusted              
                                                        0.5-hr        Derived
Species     Reference         LC50     LCLo    Time     LC (CF)        Value
______________________________________________________________________________
Rat      Izmerov et al. 1982  ----- 5.8 mg/m3  4 hr  12 mg/m3 (2.0)  1.2 mg/m3

                              
Lethal dose data:

                                                                             
                                        LD50     LDLo                  Derived
Species     Reference            Route (mg/kg)  (mg/kg)  Adjusted LD    Value
______________________________________________________________________________
Rabbit   AAPCO 1966              oral    50      -----    350 mg/m3   35 mg/m3
G. pig   AAPCO 1966              oral    33      -----    231 mg/m3   23 mg/m3
Rat      Kenaga and Morgan 1978  oral    39      -----    273 mg/m3   27 mg/m3
Mouse    Kenaga and Morgan 1978  oral    44      -----    308 mg/m3   31 mg/m3

                              
                                 
Human data . . . . . . . . . . . No effects were noted after exposure to 18
                                 mg/m3 for 1 day [Deichmann 1973].  Ingestion
                                 of 25.6 mg/kg caused convulsions within 20
                                 minutes [Ottolenghi et al. 1974].  [Note:  An
                                 oral dose of 25.6 mg/kg is equivalent to a
                                 70-kg worker being exposed to about 1,200
                                 mg/m3 for 30 minutes, assuming a breathing
                                 rate of 50 liters per minute and 100%
                                 absorption.]

Revised IDLH: 25 mg/m3
Basis for revised IDLH: The revised IDLH for aldrin is 25 mg/m3 based on acute toxicity data in humans [Deichmann 1973; Ottolenghi et al. 1974]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for aldrin at concentrations above 0.25 mg/m3.]

REFERENCES:

1. AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 7.
2. Baskin AD, ed. [1975]. Handling guide for potentially hazardous materials. Oxford, IN: The Richard B. Cross Company, PC 0180.
3. Deichmann WB [1973]. The chronic toxicity of organochlorine pesticides in man. In: Pesticides and the environment: a continuing controversy. Vol. II. New York, NY: Intercontinental Medical Book Corporation, pp. 347-420.
4. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 73.
5. Kenaga EE, Morgan RW [1978]. Commercial and experimental organic insecticides (1978 revision). Entomological Society of America Special Publication 78-1:12.
6. Ottolenghi AD, Haseman JK, Suggs F [1974]. Teratogenic effects of aldrin, dieldrin, and endrin in hamsters and mice. Teratology 9:11.