Dimethyl­1,2­dibromo­2,2­dichlorethyl phosphate (Naled)

IDLH Documentation

CAS number: 300­76­5

NIOSH REL: 3 mg/m3 TWA [skin]

Current OSHA PEL: 3 mg/m3 TWA

1989 OSHA PEL: 3 mg/m3 TWA [skin]

1993-1994 ACGIH TLV: 3 mg/m3 TWA [skin]

Description of Substance: Colorless to white solid or straw­colored liquid (above 80 F) with a slightly pungent odor.

LEL:. . Noncombustible Solid

Original (SCP) IDLH: 1,800 mg/m3

Basis for original (SCP) IDLH: Because no useful data on acute inhalation toxicity are available, the chosen IDLH has been estimated from the male rat oral LD50 of 250 mg/kg [Gaines 1969 cited by ACGIH 1971]. ACGIH [1971] also reported that the acute toxicity data, inhalation data, and experience to date indicate that this is not a highly dangerous material.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal dose data:


Species

Reference

Route
LD50

(mg/kg)
LDLo

(mg/kg)

Adjusted LD
Derived value
Mouse

Mouse

Rat

Mammal

Rat

Mouse
Berteau and Deen 1978

Berteau and Deen 1978

Berteau and Deen 1978

Debska et al. 1975

Gaines 1969

Haley et al. 1975
inhalation*

oral

oral

oral

oral

oral
156

222

160

430

250

330
-----

-----

-----

-----

-----

-----
1,092 mg/m3

1,554 mg/m3

1,120 mg/m3

3,010 mg/m3

1,750 mg/m3

2,310 mg/m3
109 mg/m3

155 mg/m3

112 mg/m3

301 mg/m3

175 mg/m3

231 mg/m3


*Note: An inhalation exposure that was presented as "mg/kg."

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 200 mg/m3

Basis for revised IDLH: The revised IDLH for dimethyl­1,2­dibromo­2,2­dichlorethyl phosphate is 200 mg/m3 based on acute toxicity data in animals [Berteau and Deen 1978, Debska et al. 1975; Gaines 1969; Haley et al. 1975].


REFERENCES:

1. ACGIH [1971]. Dibrom (naled). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 73.

2. Berteau P, Deen W [1978]. A comparison of oral and inhalation toxicities of four insecticides to mice and rats. Bulletin Environ Contam Toxicol 19:113­120.

3. Debska W, Jaruzelski M, Witkowski W, Zdziechowski J [1975]. Dynamika zanikania pestycydow w roslinach leczniczych. Herba Polonica 21:53­60 (in Polish).

4. Gaines TB [1969]. Acute toxicity of pesticides. Toxicol Appl Pharmacol 14:515­534.

5. Haley TJ, Farmer JH, Harmon JR, Dooley KL [1975]. Estimation of the LD1 and extrapolation of the LD0.1 for five organophosphate pesticides. Arch Toxicol 34:103­109.
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