|
|
CAS number: 2238075
NIOSH REL: 0.1 ppm (0.5 mg/m3) TWA; NIOSH considers diglycidyl ether to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 0.5 ppm (2.8 mg/m3) CEILING
1989 OSHA PEL: 0.1 ppm (0.5 mg/m3) TWA
1993-1994 ACGIH TLV: 0.1 ppm (0.53 mg/m3) TWA
Description of Substance: Colorless liquid with a strong, irritating odor.
LEL:. . Unknown
Original (SCP) IDLH: 25 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the male mouse 4hour LC50 of 30 ppm [Hine et al. 1956].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|
|
|
| |||
|
|
|
|
|
|
|
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 10 ppm
Basis for revised IDLH: The revised IDLH for diglycidyl ether is 10 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956; Hine et al. 1961]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for diglycidyl ether at concentrations above 0.1 ppm.] |
REFERENCES:
1. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250264.
2. Hine CH, Kodama JK, Guzman RJ, Dunlap MK, Lima R, Loquvam GS [1961]. Effects of diglycidyl ether on blood of animals. Arch Environ Health 2(1):37/3150/44.
3. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke
Latky. Prague, Czechoslovakia: Avicenum, p. 773 (in Czechoslovakian).
Go back to the Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)