Tributyl phosphate

IDLH Documentation
CAS number: 126­73­8

NIOSH REL: 0.2 ppm (2.5 mg/m3) TWA

Current OSHA PEL: 5 mg/m3 TWA

1989 OSHA PEL: 0.2 ppm (2.5 mg/m3) TWA

1993­1994 ACGIH TLV: 0.2 ppm (2.2 mg/m3) TWA

Description of substance: Colorless to pale­yellow, odorless liquid.

LEL: . . Unknown

Original (SCP) IDLH: 125 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the only available data on acute inhalation toxicity of exposure to tributyl phosphate. Patty [1963] reported that 0 of 3 rats succumbed to a 6­hour exposure to 123 ppm (1,337 mg/m3) [Fassett]. No other quantitative data are available on which to base the IDLH.

Short­term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species
Reference
LC50

(ppm)
LCLo

(ppm)
Time
Adjusted 0.5-hr

LC (CF)
Derived value
CatEller 1937
-----
2,214
5 hr
4,760 ppm (2.15)
476 ppm
CatIPCS 1991
227
-----
4-5 hr
454-488 ppm (2.0/2.15)
45-49 ppm
RatIPCS 1991
123
-----
6 hr
283 ppm (2.3)
28 ppm
RatKalinina 1971
117
-----
?
?
?
RatTSCATS
2,529
-----
1 hr
3,161 ppm (1.25)
316 ppm

Lethal dose data:

Species
Reference
Route
LD50

(mg/kg)
LDLo

(mg/kg)
Adjusted LD
Derived value
MouseKalinina 1971
oral
1,189
-----
752 ppm
75 ppm
RatSmyth & Carpenter 1944
oral
3,000
-----
1,897 ppm
190 ppm

Other animal data: It has been reported that rats survived a 6­hour exposure to 123 ppm (1,337 mg/m3) [Patty 1963].

Human data: Nausea and headache have been reported in workers exposed to 15 mg/m3 (1.4 ppm) [Mastromatteo 1964].

Revised IDLH: 30 ppm

Basis for revised IDLH: The revised IDLH for tributyl phosphate is 30 ppm based on acute inhalation toxicity data in animals [IPCS 1991]. This may be a conservative value due to the lack of relevant acute toxicity data in humans exposed to concentrations above 1.4 ppm.

REFERENCES:

1. ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600­1601.

2. Eller H [1937]. Beitrag zur toxikologie technischer weichmachungsmittel (dissertation). Pharmakologishen Institut der Universitat Wursburg, Germany.

3. Fassett DW [?]. Unpublished data from the Laboratory of Industrial Medicine, Eastman Kodak Company, Rochester, NY. [From Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1915.]

4. IPCS [1991]. Environmental health criteria 112, tri-n-butyl phosphate. Geneva, Switzerland: World health Organization, International Programme on Chemical Safety. [From ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600­1601.]

5. Kalinina NI [1971]. Toxicity of phosphoroorganic platificators tributyl phosphate and di(2­ethylhexyl)phenyl phosphate. Gig Tr Prof Zabol 15(8):30­33 (in Russian).

6. Mastromatteo E [1964]. Personal communication to TLV Committee. [From ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600­1601.]

7. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1915.

8. Smyth HF Jr, Carpenter CP [1944]. The place of the range­finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 26:269­273.

9. TSCATS. Office of Toxic Substances Report FYI­OTS­0285­0380.

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