|
|
CAS number: 117817
NIOSH REL: 5 mg/m3 TWA, 10 mg/m3 STEL; NIOSH considers disec octyl phthalate to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 5 mg/m3 TWA
1989 OSHA PEL: 5 mg/m3 TWA, 10 mg/m3 STEL
1993-1994 ACGIH TLV: 5 mg/m3 TWA, 10 mg/m3 STEL
Description of Substance: Colorless, oily liquid with a slight odor.
LEL(@474 F): 0.3% (10% LEL(@474 F), 8,600 mg/m3)
Original (SCP) IDLH*: Unknown [*Note: "Effective" IDLH = 5,000 mg/m3 -- see discussion below.]
Basis for original (SCP) IDLH: Patty [1963] made the statement that inhalation of the vapormist mixture produced by bubbling air through a column of plasticizer maintained at 170 C could be tolerated for 2 hours without producing fatalities. In a 4hour period, however, all rats had succumbed. On the basis of these experiments, the hazard to exposed workers should be very low under ordinary circumstances. Because disec octyl phthalate has such a low toxicity, respirators have been selected on the basis of the assigned protection factor afforded by each device up to 1,000 × the OSHA PEL of 5 mg/m3 (i.e., 5,000 mg/m3); only the "most protective" respirators are permitted for use in concentrations exceeding 5,000 mg/m3.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
|
| |||||
|
|
|
|
|
|
|
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 5,000 mg/m3
Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for disec octyl phthalate. Since the acute oral toxicity data in animals [Autian 1973; Shibko and Blumenthal 1973; Yagi et al. 1976] indicates that disec octyl phthalate has low acute toxicity, the revised IDLH for disec octyl phthalate is 5,000 mg/m3 based on being 1,000 times the OSHA PEL of 5 mg/m3 (1,000 is an assigned protection factor for respirators and was used during the Standards Completion Program for deciding when the "most protective" respirators should be used for disec octyl phthalate). [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for disec octyl phthalate at concentrations above 5 mg/m3.] |
REFERENCES:
1. Autian J [1973]. Toxicity and health threats of phthalate esters: review of the literature. Environ Health Perspect 4:326.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1909.
3. Shibko SI, Blumenthal H [1973]. Toxicology of phthalic acid esters used in foodpackaging material. Environ Health Perspect 3:131137.
4. Yagi Y, Tutikawa K, Shimoi N [1976]. Teratogenicity and mutagenicity
of a phthalate ester. Int J Abnorm Develop 14(2):259 [Abstract].
Go back to the Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)