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CAS number: 110805
NIOSH REL: 0.5 ppm (1.8 mg/m3) TWA [skin]
Current OSHA PEL: 200 ppm (740 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 5 ppm (18 mg/m3) TWA [skin]
Description of Substance: Colorless liquid with a sweet, pleasant, etherlike odor.
LEL(@200 F): 1.7% (10% LEL(@200 F), 1,700 ppm)
Original (SCP) IDLH: 6,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by AIHA [1963] that investigators concluded from animal experiments that substantially saturated atmospheres (6,000 ppm) at ordinary room temperatures will not produce serious injury in 1 hour [Waite et al. 1930].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
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Lethal dose data:
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Other animal data: Some investigators have stated that at ordinary room temperatures substantially saturated atmospheres (i.e., about 6,000 ppm) will not produce serious injury in 1 hour [Waite et al. 1930].
Human data: Volunteers with some work experience reported that odor levels of 125 ppm were noticeable and that the odor level that would be intolerable was greater than 255 ppm [Clayton and Clayton 1982].
| Revised IDLH: 500 ppm
Basis for revised IDLH: The revised IDLH for 2ethoxyethanol is 500 ppm based on acute inhalation toxicity data in animals [NPIRI 1974; Werner et al. 1943]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 255 ppm. |
REFERENCES:
1. AIHA [1963]. Ethylene glycol monoethyl ether (2ethoxyethanol). In: Hygienic guide series. Am Ind Hyg Assoc J 24:288289.
2. Clayton GD, Clayton FE, eds. [1982]. Patty's industrial hygiene and toxicology. 3rd rev. ed. Vol. 2C. Toxicology. New York: John Wiley & Sons, Inc., p. 3926.
3. Eastman Chemical Products [1982]. Material safety data sheet: EKTASOLVE® EE solvent. Kingsport, TN: Eastman Chemical Products, Inc., MSDS10, 170A1 (1082), pp. 17.
4. Gig Tr Prof Zabol [1963]; 32(3):4854 (in Russian).
5. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 54.
6. Waite CP, Patty FA, Yant WP [1930]. Acute response of guinea pigs to vapors of some new commercial organic compounds. III. "Cellosolve" (monoethyl ether of ethylene glycol). Public Health Rep 45:14591466.
7. Werner HW, Mitchell JL, Miller JW, von Oettingen WF [1943].
Acute toxicity of vapors of several monoalkyl ethers of ethylene
glycol. J Ind Hyg Toxicol 25:157163.
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