sec­Hexyl acetate

IDLH Documentation

CAS number: 108­84­9

NIOSH REL: 50 ppm (300 mg/m3) TWA

Current OSHA PEL: 50 ppm (300 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 50 ppm (295 mg/m3) TWA

Description of Substance: Colorless liquid with a mild, pleasant, fruity odor.

LEL:. . Unknown

Original (SCP) IDLH: 4,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that 2 of 6 rats died from a 4­hour exposure to 4,000 ppm [Smyth et al. 1954].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:


Species

Reference
LC50

(ppm)
LCLo

(ppm)

Time
Adjusted 0.5-hr

LC (CF)
Derived

value
Rat

Rat
Smyth et al. 1954

UCC 1966
LC33: 4,000

-----
-----

2,000
4 hr

4 hr
8,000 ppm (2.0)

4,000 ppm (2.0)
800 ppm

400 ppm


Lethal dose data:


Species

Reference

Route
LD50

(mg/kg)
LDLo

(mg/kg)

Adjusted LD
Derived value
Rat
UCC 1966
oral
6,160
-----
7,187 ppm
719 ppm


Human data: Volunteers noted an unpleasant odor and irritation of the eyes and upper respiratory tract at 100 ppm [Silverman et al. 1946].

Revised IDLH: 500 ppm

Basis for revised IDLH: The revised IDLH for sec­hexyl acetate is 500 ppm based on acute inhalation toxicity data in humans [Silverman et al. 1946] and animals [Smyth et al. 1954; UCC 1966].


REFERENCES:

1. ACGIH [1971]. sec­Hexyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 127.

2. Silverman L, Schulte HF, First MW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 28:262­266.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range­finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61­68.

4. UCC [1966]. Toxicology studies: methyl amyl acetate. New York, NY: Union Carbide Corporation, Industrial Medicine and Toxicology Department (7/28/66).
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