Diisobutyl ketone

IDLH Documentation

CAS number: 108­83­8

NIOSH REL: 25 ppm (150 mg/m3) TWA

Current OSHA PEL: 50 ppm (290 mg/m3) TWA

1989 OSHA PEL: 25 ppm (150 mg/m3) TWA

1993-1994 ACGIH TLV: 25 ppm (145 mg/m3) TWA

Description of Substance: Colorless liquid with a mild, sweet odor.

LEL(@200 F): 0.8% (10% LEL(@200 F), 800 ppm)

Original (SCP) IDLH: 2,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1971] report that "breathing saturated vapors in air killed 1 of 6 animals in 8 hours; breathing 2,000 ppm for 8 hours killed 5 of 6 animals. Breathing 1,000 ppm for 8 hours produced illness but no deaths." This is the only useful data available on which to base the IDLH for this substance.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:


Species

Reference
LC50

(ppm)
LCLo

(ppm)

Time
Adjusted 0.5-hr

LC (CF)
Derived

value
Rat

Rat
Smyth et al. 1949

Smyth et al. 1949
-----

2,000
2,000

-----
4 hr

8 hr
4,000 ppm (2.0)

5,000 ppm (2.5)
400 ppm

500 ppm

Lethal dose data:


Species

Reference

Route
LD50

(mg/kg)
LDLo

(mg/kg)

Adjusted LD
Derived value
Rat

Mouse

Rat
NPIRI 1974

Shell 1961

Smyth et al. 1949
oral

oral

oral
5,750

1,416

5,800
-----

-----

-----
6,799 ppm

1,674 ppm

6,858 ppm
680 ppm

167 ppm

686 ppm


Human data: It has been reported that a 3­hour exposure at 50 or 100 ppm caused slight irritation to the eyes, nose, and throat [Smyth et al. 1949].

Revised IDLH: 500 ppm

Basis for revised IDLH: The revised IDLH for diisobutyl ketone is 500 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949].


REFERENCES:

1. Carpenter CP, Pozzani UC, Weil CS [1953]. Toxicity and hazard of diisobutyl ketone vapors. AMA Arch Ind Hyg Occup Med 8:377­381.

2. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 23.

3. Shell [1961]. Unpublished report. Shell Chemical Company, p. 4.

4. Smyth HF Jr, Carpenter CP, Weil CS [1949]. Range­finding toxicity data: list III. J Ind Hyg Toxicol 31:60­62.

5. UCC [1971]. Toxicology studies: diisobutyl ketone. New York, NY: Union Carbide Corporation.
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