Diisopropylamine

IDLH Documentation

CAS number: 108­18­9

NIOSH REL: 5 ppm (20 mg/m3) TWA [skin]

Current OSHA PEL: 5 ppm (20 mg/m3) TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 5 ppm (21 mg/m3) TWA [skin]

Description of Substance: Colorless liquid with an ammonia- or fish­like odor.

LEL:. . 1.1% (10% LEL, 1,100 ppm)

Original (SCP) IDLH: 1,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1971] report that a 4­hour exposure to 1,000 ppm killed 2 of 6 rats. Patty [1963] reported the same information [Smyth et al. 1954].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:


Species

Reference
LC50

(ppm)
LCLo

(ppm)

Time
Adjusted 0.5-hr

LC (CF)
Derived

value
Rat

Mouse

Rat

Rabbit

G. pig

Cat
Izmerov et al. 1982

Izmerov et al. 1982

Smyth et al. 1954

Treon et al. 1949

Treon et al. 1949

Treon et al. 1949
1,140

1,000

LC33: 1,000

-----

-----

-----
-----

-----

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2,207

2,207

2,207
2 hr

2 hr

4 hr

2.5 hr

80 min

72 min
1,824 ppm (1.6)

1,596 ppm (1.6)

2,000 ppm (2.0)

3,752 ppm (1.7)

3,090 ppm (1.4)

2,869 ppm (1.3)
182 ppm

160 ppm

200 ppm

375 ppm

309 ppm

287 ppm


Human data: Complaints of nausea, headache, and temporary dimness in vision were reported in workers 2 to 3 hours following several 5­ to 10­minute exposures to about 176 ppm; concentrations otherwise during the workshift averaged about 24 to 48 ppm [Treon et al. 1949]

Revised IDLH: 200 ppm

Basis for revised IDLH: The revised IDLH for diisopropylamine is 200 ppm based on acute inhalation toxicity data in workers [Treon et al. 1949] and animals [Izmerov et al. 1982; Smyth et al. 1954].


REFERENCES:

1. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 54.

2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2044.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range­finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61­68.

4. Treon JF, Sigmon H, Kitzmiller KV, Heyroth FF [1949]. The physiological response of animals to respiratory exposure to the vapors of diisopropylamine. J Ind Hyg Toxicol 31:142­145.

5. UCC [1971]. Toxicology studies: diisopropyl amine. New York, NY: Union Carbide Corporation.
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