Allyl chloride

CAS number . . . . . . . . . . . 107-05-1
NIOSH REL. . . . . . . . . . . . 1 ppm (3 mg/m3) TWA, 2 ppm (6 mg/m3) STEL
Current OSHA PEL . . . . . . . . 1 ppm (3 mg/m3) TWA
1989 OSHA PEL. . . . . . . . . . 1 ppm (3 mg/m3) TWA, 2 ppm (6 mg/m3) STEL
1993-1994 ACGIH TLV. . . . . . . 1 ppm (3 mg/m3) TWA, 2 ppm (6 mg/m3) STEL
Description of substance . . . . Colorless, brown, yellow, or purple liquid
                                 with a pungent, unpleasant odor.
LEL. . . . . . . . . . . . . . . 2.9% (10% LEL, 2,900 ppm)
Original (SCP) IDLH. . . . . . . 300 ppm
Basis for original (SCP) IDLH. . The chosen IDLH is based on the statement by
                                 Deichmann and Gerarde [1969] that a 1-hour 
                                 exposure to 300 ppm might cause serious
                                 effects.
Short-term exposure guidelines . None developed

ACUTE TOXICITY DATA

Lethal concentration data:

                                                       Adjusted    
                                                        0.5-hr         Derived
Species       Reference        LC50      LCLo   Time    LC (CF)         Value
______________________________________________________________________________
Rat     Boqin et al. 1982  11,000 mg/m3  -----  2 hr  4,323 ppm (1.25) 434 ppm
Mouse   Boqin et al. 1982  11,500 mg/m3  -----  2 hr  4,520 ppm (1.25) 452 ppm
G. pig  Boqin et al. 1982   5,800 mg/m3  -----  2 hr  2,280 ppm (1.25) 228 ppm
Rabbit  Boqin et al. 1982  22,500 mg/m3  -----  2 hr  8,844 ppm (1.25) 884 ppm
Cat     Boqin et al. 1982  10,500 mg/m3  -----  2 hr  4,127 ppm (1.25) 413 ppm

Human data . . . . . . . . . . . It has been stated that a 1-hour exposure to
                                 300 ppm might cause serious effects
                                 [Deichmann and Gerarde 1969].

Revised IDLH: 250 ppm
Basis for revised IDLH: The revised IDLH for allyl chloride is 250 ppm based on acute inhalation toxicity data in humans [Deichmann and Gerarde 1969] and animals [Boqin et al. 1982].

REFERENCES:

1. Boqin L, Shuwei D, Airu Y, Yinlin X, Taibao G, Tao C [1982]. Studies on the toxicity of allyl chloride. Ecotoxicol Environ Safety 6(1):19-27.
2. Deichmann WB, Gerarde HW [1969]. Allyl chloride. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., pp. 86-87.