Ethyl butyl ketone

IDLH Documentation

CAS number: 106­35­4

NIOSH REL: 50 ppm (230 mg/m3) TWA

Current OSHA PEL: 50 ppm (230 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 50 ppm (234 mg/m3) TWA

Description of Substance: Colorless liquid with a powerful, fruity odor.

LEL:. . Unknown

Original (SCP) IDLH: 3,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Patty [1963] and Deichmann and Gerarde [1969] that 0 rats died following a 4­hour exposure to 2,000 ppm, but 6 of 6 rats died following a 4­hour exposure to 4,000 ppm [Smyth et al. 1949].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:


Species

Reference
LC50

(ppm)
LCLo

(ppm)

Time
Adjusted 0.5-hr

LC (CF)
Derived

value
Rat
Smyth et al. 1949
LC100: 4,000
-----
4 hr
8,000 ppm (2.0)
800 ppm


Lethal dose data:


Species

Reference

Route
LD50

(mg/kg)
LDLo

(mg/kg)

Adjusted LD
Derived value
Rat
Smyth et al. 1949
oral
2,760
-----
4,067 ppm
408 ppm


Other animal data: It has been reported that rats survived a 4­hour exposure to 2,000 ppm [Smyth et al. 1949].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 1,000 ppm

Basis for revised IDLH: The revised IDLH for ethyl butyl ketone is 1,000 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949].


REFERENCE:

1. Deichmann WB, Gerarde HW [1969]. Table 50. Toxicity of ketones. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 736.

2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1741.

3. Smyth HF Jr, Carpenter CP, Weil CS [1949]. Range­finding toxicity data: list III. J Ind Hyg Toxicol 31:60­62.
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