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NIOSH REL: 0.14 ppm (0.6 mg/m3) 2hr CEILING [skin]; NIOSH considers phenylhydrazine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 5 ppm (22 mg/m3) TWA [skin]
1989 OSHA PEL: 5 ppm (20 mg/m3) TWA, 10 ppm (45 mg/m3) STEL [skin]
1993-1994 ACGIH TLV: 0.1 ppm (0.44 mg/m3) TWA [skin], A2
Description of substance: Colorless to paleyellow liquid or solid (below 67°F) with a faint, aromatic odor.
LEL:. . Unknown
Original (SCP) IDLH*: 295 ppm [*Note: "Effective" IDLH = 250 ppm -- see discussion below.]
Basis for original (SCP) IDLH: No data on acute or chronic inhalation toxicity are available on which to base the IDLH. Systemic effects described by Patty [1963] were caused by chronic exposures from oral dosing. NIOSH [1976] cited a rat oral LD50 of 188 mg/kg [Ekshtat 1965] which provides a calculated estimate of 1,300 mg/m3 (295 ppm) for the IDLH. Because of the assigned protection factor afforded by each device, however, 50 ´ the OSHA PEL of 5 ppm (i.e., 250 ppm) is the concentration above which only the "most protective" respirators are permitted.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal dose data:
| Rat
Mouse Rabbit G. pig Dog | Ekshtat 1965 Ekshtat 1965 Ekshtat 1965 Ekshtat 1965 Ekshtat 1965 |
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Human data: None relevant for use in determining the revised
IDLH.
| Revised IDLH: 15 ppm
Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for phenylhydrazine. Therefore, the revised IDLH for phenylhydrazine is 15 ppm based on acute oral toxicity data in animals [Ekshtat 1965]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for phenyl hydrazine at concentrations above 0.14 ppm.] |
REFERENCES:
1. Ekshtat BY [1965]. Maximum permissible concentrations of hydrazine hydrate and phenylhydrazine in water bodies. Gig Sanit 30(8):191197 (translated).
2. NIOSH [1976]. MV89250. Hydrazine, phenyl. In: Registry of toxic effects of chemical substances, 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76191, p. 598.
3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd
rev. ed. Vol. II. Toxicology. New York, NY: Interscience
Publishers, Inc., pp. 22272228.
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