CAS number: 100378
NIOSH REL: 10 ppm (50 mg/m3) TWA [skin]
Current OSHA PEL: 10 ppm (50 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 10 ppm (48 mg/m3) TWA [skin]
Description of Substance: Colorless liquid with a nauseating, ammonialike odor.
LEL:. . Unknown
Original (SCP) IDLH: 500 ppm
Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for diethylaminoethanol. The chosen IDLH is based on the following statements by Cornish [1965]: "exposure of rats to 500 ppm, 6 hours daily for 5 days, resulted in severe weight loss and high mortality. Daily exposure at 200 ppm resulted in the death of 7 of 50 rats during the first month. A single human exposure for a few seconds to a level well below 200 ppm resulted in nausea and vomiting."
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
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Lethal dose data:
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Human data: A very short exposure (<30 seconds) to a concentration estimated to be less than 100 ppm has resulted in nausea and vomiting within 5 minutes; other persons in the same room also complained of the nauseating odor but did not become ill [Cornish 1965].
Revised IDLH: 100 ppm
Basis for revised IDLH: The revised IDLH for 2diethylaminoethanol is 100 ppm based on acute inhalation toxicity data in humans [Cornish 1965]. |
REFERENCES:
1. Cornish HH [1965]. Oral and inhalation toxicity of 2diethylaminoethanol. Am Ind Hyg Assoc J 26:479484.
2. Lomonova GV [1970]. Toxicology data on dimethylethanolamine and diethylethanolamine. Gig Tr Prof Zabol 14(11):5253 (translated).
3. Smyth HF Jr, Carpenter CP [1944]. The place of the rangefinding
test in the industrial toxicology laboratory. J Ind Hyg Toxicol
26:269273.
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